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Mitochondrial dysfunction and oxidative stress constitute central mechanisms in MASH pathogenesis, with MASLD progression closely linked to mitochondrial impairment (69)
Additionally, glutathione is involved in various metabolic and biochemical processes, making it indispensable for overall health and well-being
Available from: Chandrawanshi D, Harinkhede K, Turkar K, Patle K, Katre H, Bisen A
Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above
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