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Annu Rev Biochem 1988

15 As such, GIP, secreted by enteroendocrine K-cells, and GLP-1, released from corresponding intestinal L-cells, collectively referred to as the incretin hormones, are well-studied for their roles in glucose homeostasis and energy balance

Y respecto de la pancreatitis , apunt que tambin se hicieron estudios con mejor diseo buscando especficamente este efecto adverso y se demostr que no est asociado al frmaco sino que se relaciona con la prdida de peso de manera muy abrupta , ms del 1% del peso corporal por semana, y tambin est descripto en la ciruga baritrica y en las dietas muy restrictivas