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In general, serious side effects from B12 injections are rare but in some cases, people may experience a few mild ones including pain, redness, or bruising at the site of injection

That includes people who: have a history of cancer or are under active cancer evaluation are pregnant or breastfeeding have autoimmune or inflammatory disease that is already hard to stabilize are taking multiple other agents and cannot tell what is doing what are using the compound without a clinician who understands the tradeoffs That is not a verdict

Renal cell carcinoma cell lines lacking pVHL were no longer able to grow into tumors in mice when pVHL was reintroduced in these cell lines[61]

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