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This Mayo study titled, Performance of a Machine-Learning Gene Risk Score Biomarker on Predicting Response to Semaglutide, enrolled 84 participants with obesity (BMI 38.86.9 kg/m2) who were prescribed semaglutide
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2-4 Weeks: Early Weight Loss By weeks 2-4, many patients begin to see measurable results: Initial weight loss often becomes noticeable on the scale Average weight loss ranges from 2-5 pounds during this phase Side effects, if any, typically stabilize Portion sizes naturally decrease as satiety signals improve This early period is when most patients start feeling encouraged by visible progress
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