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GSH can oxidize after cells or tissues are collected, which can make GSH look lower and GSSG look higher than they were in the original sample
doi: 10.1016/j.cell.2022.01.014 79 WangKKhoramjooMSrinivasanKGordonPMKMandalRJacksonDet al
The results mirror a previous observation from our group, that hypothalamic Gipr KO appeared to sensitize DIO mice to weight loss induced by a long-acting GLP-1R agonista finding that had not been the focus of that study and remained unexplained at the time but has since also been observed in global GIPR-KO mice 7,11
Tumors in this group tend to be of high grade and get metastasized in the early time course of the disease
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