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These findings suggest that the addition of GLP-1 receptor agonists to metformin therapy may mitigate certain serious adverse effects associated with metformin monotherapy
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A key concept here is functional hypothalamic amenorrhoea (FHA) , a condition in which the hypothalamus reduces its secretion of gonadotrophin-releasing hormone (GnRH), leading to lower levels of luteinising hormone (LH) and follicle-stimulating hormone (FSH)
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