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Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

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For others, it means extending the time at each dose level, spending eight to twelve weeks at 2.5 mg before moving to 5 mg instead of the standard four weeks

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