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Indeed, cAMP levels can be elicited by GLP-1 treatment of mouse cardiomyocytes without increasing intracellular Ca 2+ or inducing contractility [38]

( f-g ) H4K12ac or H3K23ac chromatin immunoprecipitation in U2OS-mCherry-LacI-Fok1 cells treated with the IDH1 inhibitor ( f ) or transduced with shRNA targeting TMLHE (shTMLHE) ( g ) alone or supplemented with KG or l-carnitine (l-carn) supplementation (n = 3 technical replicates representative from 2 independent experiments)

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