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Tolerogenic DCs are characterized by increased anti-inflammatory markers (IL-10 and TGF- ) and decreased pro-inflammatory cytokines, with a developmental state described as semi-mature ( Metabolic modulation via metformin treatment has also shown promise in inflammatory diseases by inducing tolDCs and driving subsequent Treg generation
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Oral administration allows for easy daily use without the discomfort, complexity or potential side effects associated with injections
In an AD mouse model, GLP-1RAs were demonstrated to reduce the levels of AD pathological markers, including oligomeric antibodies and antibody plaque load, reduce the activation of microglia, and improve memory behavior (35, 44, 45)
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