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Los IDPP-4 han sido ampliamente aceptados en la prctica clnica, con un incremento progresivo en su uso100 debido a su seguridad, bajo riesgo de hipoglicemia, efectos neutros en el peso, fcil dosificacin y administracin oral
Retatrutide is injected subcutaneously (under the skin) once a week and is currently being tested for treating obesity
The REDEFINE 2 trial examined the combination in adults with type 2 diabetes, where weight loss is typically harder to achieve due to insulin resistance and medication effects
The mean estimated FVC% was 98.8 at baseline, 67.4 at month 12 and 36.2 at month 24 in treated subjects, with a mean slope of 2.6, as compared to 101.4, 61.9 and 22.5 in not treated subjects, with a mean slope of 3.3 (slope difference: 0.7
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