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Effects of growth hormone on insulin resistance and atherosclerotic risk factors in obese type 2 diabetic patients with poor glycaemic control
The literature identifies hypoglycemia as the most significant documented risk, driven by IGF-1 LR3s effect on cellular glucose uptake, alongside receptor desensitization with prolonged exposure and contraindications for individuals with a history of malignancy
Instead, it modulates several intersecting biological systems, which helps explain both its broad tissue effects and the complexity of establishing a clean dose-response relationship
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