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Mitochondria generate the majority of cellular ROS as a byproduct of oxidative phosphorylation, and mitochondrial GSH is the primary defense against this constant oxidative burden
If it is not enough, your body will not be able to clean itself up
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To address the major differences in glutaredoxin activities, we previously suggested two nonexclusive working models for glutaredoxin catalysis termed glutathione scaffold and glutathione activator model
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