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During the CDR, the mitochondria intentionally downregulate ATP production, shifting their focus from energy generation to cellular defense
In contrast, RAMP1/3 KO mice exhibited disrupted metabolic responses: Cagrilintide treatment increased relative fat mass and decreased lean mass, along with elevated leptin and insulin levels
Together, they address NAD+ depletion from both the supply side (more NAD+) and the waste side (less precursor degradation)
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