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As with any treatment, pregnant or breastfeeding women should consult their healthcare provider before using the patch to avoid any potential risks
One study conducted on rats found IGF-1 administration to increase excitatory synaptic transmission in CA1 by 40%
Reported cases have occurred primarily in diabetic patients with significant renal insufficiency, including both intrinsic renal disease and renal hypoperfusion, often in the setting of multiple concomitant medical/surgical problems and multiple concomitant medications
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