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Animal experiments All animal procedures were performed in accordance with the Guidelines for the Ethical Review of Laboratory Animal Welfare (GB/T35892-2018) and approved by the Experimental Animal Ethics Committee of the Fifth Affiliated Hospital of Sun Yat-sen University
Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]
In April 2025, the company discontinued its main obesity candidate, danuglipron, due to safety concerns
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