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The average association rate constant, k a (M 1 s 1 ) for GLIP-C1 F27 was 8.4x10 4 (8.7x10 4 M 1 s 1 at a concentration of 2 g/ml GLIP-C1 F27 and 8.1x10 4 M 1 s 1 at a concentration of 20 g/ml) whereas the association rate constant for NNC1212-7148 and NNC1212-7141 was 2.8x10 5 M 1 s 1 and 3.7x10 5 M 1 s 1 , respectively, as illustrated in 4

It is important to note that berberine supplements are not subject to the same rigorous regulatory oversight as licensed medicines

2 GLP-1 GIP () GLP-1 (-1) 2 GLP-1 GLP-1L GLP-1 () GLP-1

Sarah Whitmires affiliation has changed since the completion of the study, and since Jan 2020 she is a full-time employee of Novo Nordisk Inc