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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

Exenatide weekly was also associated with improvements in low-density lipoprotein (LDL) within two of the trials and no other drug in the trial saw these improvements 6

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