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Sleep deprivation disrupts hormones that regulate appetite (increasing ghrelin and decreasing leptin) and impairs glucose metabolism
Shannon Chris E
Notably, about one in four of these patients did not carry a type 2 diabetes diagnosis , suggesting that a substantial portion of GLP-1 use is being driven by weight loss and other emerging indications outside of diabetes care (Figure 2)
Generation of GM mice with the MLC enhancer incorporated in site 2 To extend our study from cell lines to a whole animal context, we generated genetically modified mice by injecting Cas9 mRNA, sgRNA targeting site 2 and the circular donor plasmid into mouse zygotes (Table 1)
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