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More significant structural improvements reduced fine lines, improved firmness, better skin density typically become visible between weeks 8 and 12, with continued improvement through months 4 to 6 as collagen remodeling matures
doi: 10.1016/j.jep.2024.119040 99
The mechanisms are mostly indirect: shifted fluid balance from weight loss, increased water intake to manage nausea, and metabolic changes from the drug itself
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