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Always use ice packs around eyes or to the forehead
Darkened skin patches A B12 shortage can affect melanin activity, causing darker areas near the mouth or eyes
Larger doses of vitamin B12 can cause other more serious side effects including: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet Our doses are preservative free and extremely small, and therefore rarely cause a negative reaction
no separate PDA trial base as of April 2026
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