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231 utilized a chromatin immunoprecipitation (ChIP) assay to determine that the human adipose tissue H3K4me3 histone mark site in adipogenic, lipid metabolism, and inflammatory genes (such as LEP , LPL , SREBF2 , SCD1 , PPARG , IL6 , TNF , and E2F1 ) is positively associated with BMI and HOMA-IR