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Risk-of-bias assessment The methodological quality of included RCTs was assessed utilizing the Cochrane Risk of Bias 2 (RoB2) tool [18], while observational studies were evaluated with the Risk Of Bias In Non-randomized Studiesof Interventions (ROBINS-I) [19]

Z.HayakawaK.WangX.GerhardingerC.LoE

employed 4-Nitroquinoline N-oxide (4NQO), a known mutagen that mimics the effects of smoking and generates oxygen free radicals, to induce DNA damage in HPV-positive cells