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Of note, incidence of MTC was extremely low in all of the large cardiovascular outcome trials with no significant increase seen in GLP-1RA-treated individuals, although it should be highlighted that some of the trials did have a family history of MEN-2 as an exclusion criterion
GLP-1 receptor agonists have also shown success in other therapeutic areas apart from type 2 diabetes and obesity, in particular for non-alcoholic fatty liver disease [104]
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