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10.1373/clinchem.2011.174490 20 IshikuraK.RaS.-G.OhmoriH
These effects are thought to occur through GLP-1s influence on both peripheral (vagal) and central pathways, including the hindbrain, hypothalamus, and brain regions involved in motivation and reward, which help regulate appetite and metabolism [8, 14, 18]
However, over time, the pancreas may become exhausted and unable to keep up with the demand for insulin, leading to type 2 diabetes.Insulin resistance is also associated with other metabolic abnormalities, including high levels of triglycerides and low levels of HDL cholesterol, a condition known as dyslipidemia
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