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At 2-fold the maximum recommended daily dose (~3-fold the steady-state exposure for sertraline and N-desmethylsertraline), the largest mean QTc was 10 ms with upper bound of two-sided 90% confidence interval of 12 ms
Regular and unexplained discoloration of urine over the course of many days
And the next dose should be administered on the regularly scheduled day
One big question is whether tirzepatide can hurt the kidneys or make kidney disease worse
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