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0.9%), and 0.75 mg of dulaglutide (PIONEER 10: baseline HbA1c 8.3%, 1.7% vs
In clinical trials, patients using injectable semaglutide lost an average of 15% to 16% of their body weight over 64 weeks, while those using an oral semaglutide formulation lost approximately 13%. The difference is meaningful but modest, and for many people the convenience and lower friction of an oral format may more than offset a slightly lower average weight loss
That low (and variable) uptake is why dosing conditions matter so much and why youll see careful instructions around taking it on an empty stomach with limited water and waiting before food/other meds
They also have very different costs associated with them, which can be a big part of choosing one or the other for some people
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