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17.1% on 4mg (NEJM, Jastreboff 2023) No plateau: Weight was still declining at 48 weeks in Phase 2 and continued through 68 weeks in Phase 3 Body composition: 74% of weight lost was fat mass, 26% lean mass, based on DEXA scan data from Phase 2 Realistic range: Most people starting retatrutide should expect 1525% weight loss over 1218 months at therapeutic doses, assuming reasonable adherence and lifestyle changes Not FDA-approved: Currently investigational

"If a cyclist falls and breaks a bone, we call it a fracture and not a bicycle fall," Xie said

Avoid exfoliating acids before applying peptides