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GLP-1 agents demonstrate 15-22% reduction over 68 weeks in trials (tirzepatide) and 10-15% over similar periods (semaglutide)

The high need for trials assessing functional outcome after stroke rather than stroke prevention with GLP-1 agonists and DPP-4 inhibitors

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Receptor Mechanism Compared All three engage class B G-protein coupled receptors that signal through Gs coupling, adenylyl cyclase activation, and cAMP elevation