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The cardiovascular benefits of this pairing extend beyond weight lossboth medications independently reduce heart disease risk, and together they lower the incidence of major adverse cardiovascular events (MACE) in high-risk populations

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Together, these two pathways produce more pronounced appetite suppression and metabolic effects than either hormone alone

We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling