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Sodium, potassium, and magnesium support blood pressure stability, nerve signaling, and cardiovascular function when fluid balance shifts during GLP-1 treatment
Adding bupropion constipation on top of tirzepatide constipation creates a compounded problem that may require proactive management with fiber supplements and hydration
If side effects persist beyond 12 weeks despite dose adjustments and dietary strategies, PlexusDx can transition you to tirzepatide injection (is $289/mo month-to-month (or $249/mo on the 6-month plan)) or oral semaglutide ($289/mo), which may be better tolerated
Starting assumptions for a hypothetical 220 lb (100 kg) patient: Baseline BMR: approximately 2,000 calories/day Total daily expenditure (TDEE): approximately 2,400 calories/day (sedentary) Retatrutide effects on the energy equation: Caloric intake reduction: 25-35% (based on food intake data) = 600-840 fewer calories consumed Estimated thermogenic increase: 5-10% of BMR = 100-200 additional calories burned Combined daily deficit: 700-1,040 calories At 48 weeks, this deficit accounts for approximately 54-80 pounds of weight loss, aligning with observed clinical results
