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If the injection is given IV (slowly), there may be a brief sensation of warmth or a mild flushing during the infusion, owing to the niacinamide component
Additionally, GLP-1RA reduced the production of various of AGEs-induced catabolic factors (MMP1, MMP3, MMP13, ADAMTS4 and ADAMTS5), preventing matrix degeneration, while promoting anabolism
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The trade-off was injection site reactions (small nodules) in some patients, since the microspheres reside under the skin for weeks
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