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These structural alterations in regions relevant to mood regulation suggest a neuroanatomical link between T2DM and depression
The GLP-1R agonist exendin-4 was shown to promote neurogenesis in the subventricular zone region in a neurodegenerative disease rodent model (Li et al., 2009
As a research reagent it is used to probe type 1 IGF receptor activation, downstream PI3K and MAPK signalling, IGF binding protein biology, and the specific question of how much native IGF-I behaviour reflects IGFBP sequestration rather than receptor pharmacology
It's commonly used in topical skincare (serums, creams) for skin rejuvenation and is also used in some injectable or wound-healing protocols
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