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Benefits: Increasing glutathione levels through precursors may help protect against oxidative stress, support liver health, and potentially benefit conditions like neurodegenerative diseases
Other Key Findings Metabolic improvements: Participants saw reductions in A1C (for those with prediabetes or diabetes), fasting glucose, and triglycerides Liver fat reduction: Retatrutide reduced liver fat by up to 50%, which is why Eli Lilly added a NASH-specific trial to the Phase 3 program Side effects: Mostly gastrointestinal (nausea, diarrhea, constipation), similar to other GLP-1 drugs but manageable with slow titration Discontinuation rate: About 10% of participants stopped due to side effects, comparable to tirzepatide and semaglutide Study limitation: The Phase 2 trial was only 48 weeks long
In some parts of the world, methionine (10%) is included in acetaminophen products to protect against accidental intoxication
Keeping water intake high and fiber steady are the two best tools for preventing this from becoming a problem
