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Pregnancy and breastfeeding require clinician guidance Because safety evidence is limited in pregnancy and breastfeeding, those situations should be handled conservatively and individually

We investigated two common TYMS polymorphisms in 94 MDS and 113 control mothers of Italian origin (Copped et al., 2009), namely a 28-bp short tandem repeats (rs34743033) in the 5-untranslated region (5-UTR) that is linked to gene expression levels (Horie et al., 1995), and a 6-bp deletion (1494 ins/del) polymorphism in the 3-UTR (rs34489327) that affects mRNA stability into the cytoplasm (Ulrich et al., 2002)

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