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Completion of the trials main phase is expected in September 2025, and the 52-week extension (in which participants and investigators remain blinded to treatment assignment) will continue to October 2026

In a manually reviewed sample of 288 people classified as discontinuers, cost or insurance was the documented primary reason for 137, side effects for 42, and shortages for 34

These are summarized in Fig

Future research objectives must concentrate on creating prediction algorithms for appropriate receptor targeting ratios, exploring triple-agonist strategies (GLP-1/GIP/glucagon), and determining long-term safety profiles for multi-receptor therapies