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Sleep is equally relevant: testosterone is primarily produced during sleep, and research has found that even one week of sleeping five hours per night reduces testosterone levels by approximately 10 to 15% in young men, a reduction equivalent to ageing ten to fifteen years

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This fatigue is not related to stimulant withdrawal but may reflect caloric restriction, gastrointestinal side effects, or metabolic adaptation

The platelet-rich layer is extracted and concentrated, resulting in a plasma solution with 3-10x the normal platelet concentration