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PubMed Central , Redox Biology , vol

Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency

In one randomized controlled trial that included 60 participants with a BMI of 35 or higher and type 2 diabetes for 5 years, 75% of those who underwent gastric bypass surgery and 95% of those who underwent a type of metabolic surgery known as biliopancreatic diversion were diabetes-free two years later, but no one treated with non-surgical interventions alone experienced diabetes remission (Mingrone 2012)

While possession is not illegal (they are not DEA-scheduled substances), the regulatory landscape continues to evolve