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NAC group (rats were injected intraperitoneally with MTX on day 7 plus NAC 500 mg/kg/day throughout the experiment by oral gavage, plus Kolliphor EL from day 1- day 10) (Li et al., 2018
In addition, RvE1 protects vascular endothelial cells by limiting leukocyte adhesion and transmigration, mitigating systemic inflammationinduced endothelial dysfunction, and preserving vascular barrier integrity by regulating microvascular permeability [120]
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75 Both environmental and genetic factors are critical in a local cellular milieu where tumors initiate and determine the fate of cells
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