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This applies to unlicensed medicines as well as licensed ones, and your report helps build the UK's understanding of emerging medicines and their real-world safety
In addition to exacerbating gliosis and inflammation, BBB disruption also leads to oxidative damage such as in ischemia-reperfusion injury where SOD1 deficiency causes exacerbated neuronal damage and infarct volume (Gasche et al., 2001)
Singh et al., 2023)
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