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Mild bloating and stomach discomfort at higher doses is occasionally reported

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PAMPs can be broadly categorized into several groups: microbial surface components such as peptidoglycans and LPS from bacterial cell walls, mannans and -glucans from fungal cell walls, and flagellin, the protein component of bacterial flagella

Centrilobular (Figures 5459) Sometimes referred to as periacinar necrosis, it consists of irreversible cell death of centrilobular hepatocytes and is often seen after anoxia, or exposure to tannic acid, chloroform, or other hepatotoxic agents (Gopinath, Prentice, and Lewis 1987)