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GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols
Relationship of cytosolic glutathione to efflux and mitochondrial sequestration
Compound that with the enamel erosion that can come from vomiting, gastroesophageal reflux disease (GERD), or acid reflux (all of which can be caused by a GLP-1), and your mouth is more likely to experience things like cavities, tooth sensitivity, gingival inflammation, and taste disturbances
Death from metastatic MTC most commonly occurs during the second or third decade, but there are well-described examples of patients with metastatic disease who have had prolonged survival (113,118).
