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Runge et al

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Indeed, in the first report that demonstrated a significant role of ceramide in erythrocyte death pathways, it has been ruled out that the elevated ceramide levels originate from the biosynthetic pathway [122]

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335 In response to l-lactate, cGAS associates with the alanyl-tRNA synthetases alanyl-tRNA synthetase 1 (AARS1) and AARS2 (AARS1/2), which function as intracellular l-lactate sensors

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Without these interventions, both sexes risk losing up to 30% of total weight as muscle rather than fat

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