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The percentage of blood double-positive T cells, a hallmark of T cell receptor (TCR) engagement, was also increased in patients with higher histidine serum concentrations (Extended Data Fig
Berberine, an alkaloid extracted from traditional Chinese medicine, binds to the bitter taste receptor TAS2R38 and activates the PLC signaling pathway to stimulate GLP-1 secretion in STC-1 cells [193]
Furthermore, the Delphi statements and patient profiles predominantly focused on adults with normal or elevated BMI, reflecting the high prevalence of overweight/obesity in T2D and CKD
Among the 24 randomized participants, 22 (91.7%) were male, and 2 (8.3%) were female (Table 1)
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