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[5] Additionally, some patients may experience changes in lipid profiles, liver enzymes, or kidney function markers as their metabolic health improves or if side effects such as dehydration from gastrointestinal symptoms develop
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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (1518, 71)
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