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NRF2 stimulates the production of heme oxygenase-1 (HO-1) and the accumulation of Fe 2+ in LIP as well as the release of iron from hemoglobin, hence inducing ferroptosis
Anti-inflammatory genes upregulate while pro-inflammatory pathways decrease
(110), curcumin promoted iron apoptosis in colorectal cancer by controlling the expression of vital iron apoptosis indicators Fer 1, SLC7A11, GSH, MDA, and ROS through the PI3K/mTOR pathway
Hangover IV therapy is generally well tolerated for healthy adults when administered by trained medical professionals using proper screening protocols
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