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This chronic sympathetic activation not only causes anxiety, insomnia, and rapid heart rate, but it also signals to the innate immune system that the body is under constant threat, further provoking mast cell degranulation

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Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss