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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

A study that compared 24 obese patients with MC-4R deficiency to 80 healthy controls (40 obese and 40 lean) found that those with MC-4R mutations consumed significantly more high-fat meals

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