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10.1371/journal.pone.0072046 PLoS ONE 35 GaoH.-M.LiuB.HongJ.-S
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Clinicians managing patients on testosterone who wish to explore retatrutide should: Consult the relevant clinical trial protocols if the patient is enrolled in a study Seek specialist endocrinology input before initiating any off-label or investigational combination Document clinical rationale clearly , obtain informed consent, and follow GMC Good Practice in Prescribing and Managing Medicines and Devices guidance when considering unlicensed or investigational treatments Until formal guidance is available, clinical decision-making should be guided by individual patient riskbenefit assessment, informed consent, and regular monitoring
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