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A 2017 randomised controlled trial found that 500mg oral glutathione twice daily for 12 weeks produced 17.6% mean melanin index reduction in melasma patients vs 2.1% placebo
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Modification of the protocol Any modifications to the study protocol that may influence study conduct, patient benefit, or safetysuch as changes in study objectives, design, participant population, sample size, procedures, or major administrative aspectswill require a formal amendment
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