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Adding tirzepatide on top may intensify these symptoms initially

47 Interestingly, in the meta-analysis by Esposito et al comparing liraglutide and exenatide, the best predictor of achieving the target HbA1c level was the baseline HbA1c

There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5

Its helpful to pace yourself and avoid overexertion, especially if youre on semaglutide